Year8
'r ',,, boldface, '',, Sofosbuvir tablets, a new drug for the treatment of hepatitis C, has put the controversial US health care reform into another dilemma. Unable to solve the health insurance cost problem, some states, represented by Oregon, are seeking ways to limit the supply of the drug. As a result, the expanded Medicaid program proposed in President Obama's health care reform plan has been greatly reduced.
'r ',,, 黑体, '',, , Usage and Dosage
'r ',,, 黑体, '',, Each tablet, one tablet a day, take on an empty stomach or with food
'r ',,, boldface, '',, can be combined with ribavirin or combined with ribavirin + pegylated interferon to treat chronic hepatitis C (). The recommended combination treatment plan is as follows:
'r ',,, bold body, '',, , single infection
'r ',,, black body, '',, or/- combined infection treatment plan Duration
'r ',,, boldface, '',, genotype or type sofosbuvir+peginterferon-&+ribavirin weeks
'r ',,, Bold body, '',, genotype sofosbuvir + ribavirin weeks
'r ',,, bold body, '',, genotype sofosbuvir + ribavirin weeks
'r ',,, bold, '',, patients with chronic hepatitis C who are unable to use interferon may consider using sofosbuvir combined with ribavirin for weekly treatment.
'r ',,, boldface, '',, Hepatocellular carcinoma patients awaiting liver transplantation should be treated with sofosbuvir combined with ribavirin for chronic hepatitis C for weeks or until liver transplantation, whichever occurs first shall prevail.
'r ',,, boldface, '',, Dosing recommendations cannot be made for patients with severe renal impairment or end-stage renal disease.
'r ',,, boldface, '',, , dosage form
'r ',,, boldface, '',, each tablet: .
'r ',,, boldface, '',, , contraindications
'r ',,, boldface, '',, & Sofosbuvir combined with pegylated interferon-&+ All contraindications for peginterferon-&/or ribavirin when used alone or in combination with ribavirin also apply to sofosbuvir combination therapy.
'r ',,, boldface, '',, & Since ribavirin may cause fetal congenital malformation or stillbirth, [] sofosbuvir combined with pegylated interferon&+ribavir Lin, or sofosbuvir alone in combination with ribavirin should be contraindicated in pregnant women and men whose partners are pregnant.
'r ',,, boldface, '',, , indications and uses
'r ',,, boldface, '',, Sofosbuvir is a type of hepatitis C virus () Nucleotide analog B polymerase inhibitor is suitable for use as a combination component in a combined antiviral treatment regimen for the treatment of chronic hepatitis C (HCV) infection.
'r ',,, boldface, '',, Sofosbuvir has been proven effective in the treatment of genotype, , or hepatitis C in subjects, including subjects with hepatocellular carcinoma who meet the Milan criteria and are waiting for liver transplantation. and/- coinfected subjects.
'r ',,, boldface, '',, , Warnings and Precautions
'r ',,, boldface, '',, Pregnancy: Ribavirin may cause fetal congenital malformations or Stillbirths occur, and animal experiments show that interferon can induce miscarriage. Therefore, female patients taking this drug and the spouses of male patients should avoid becoming pregnant. Before starting treatment, patients must have a negative pregnancy test, use at least two non-hormonal methods of contraception, and undergo monthly pregnancy tests.
'r ',,, boldface, '',, , adverse reactions
'r ',,, boldface, '',, the most common known adverse reactions caused by sofosbuvir combined with ribavirin Adverse reactions (incidence equal to or greater than %, all grades) are headache and fatigue. The most common adverse reactions known to be caused by sofosbuvir combined with peginterferon-& ribavirin include fatigue, headache, nausea, Insomnia and anemia.
'r ',,, boldface, '',, , drug interactions
'r ',,, boldface, '',, potent intestinal glycoprotein(-) inducers (e.g. Rifampin) may alter sofosbuvir drug plasma concentrations. Before use, please read the complete package insert for drug-drug interactions.
'r ',,, boldface, '',,
WhatsApp
