Product Details
'r ',) Tarceva's mode of action is different from that of chemotherapy. It is a targeted therapy drug that can specifically target tumor cells and inhibit the formation and growth of tumors.
_b> 'r ', () Tarceva is a small molecule compound that inhibits the signaling pathway of human epidermal growth factor receptor (R). It is a key component of the epidermal growth factor (also known as R) signaling pathway and plays an important role in the formation and growth of various tumor cells.
'r ', () Tarceva inhibits tumor growth by inhibiting the activity of tyrosine kinase, which is one of the important components in R cells.
'r ', Tarceva has significant efficacy in the treatment of lung cancer
'r ', Tarceva is currently the only R inhibitor that has been proven to have a survival advantage in the treatment of lung cancer. In the landmark Core Study BR. study, patients with progressive disease were studied.
'r ', The study confirmed that patients taking Tarceva significantly improved their survival compared with the control group, with the median survival improved by .% (overall survival: .months vs. .months). % of patients in the Tarceva group survived for more than 10 years, while only % in the control group. The control of tumor-related symptoms of patients in the Tarceva group is also longer than that of the control group, which can significantly improve the quality of life and body functions.
'r ', Tarceva has a good effect in the treatment of pancreatic cancer
'r ', In a randomized phase III clinical study (.) conducted on patients with progressive or metastatic pancreatic cancer, the data showed: < br/> 'r ', () The progression-free survival of patients in the Tarceva combined with gemcitabine group was significantly prolonged
'r ', () The Tarceva/gemcitabine combination regimen was well tolerated and did not increase hematopoietic system adverse effects. Response
'r ', () % of patients in the Tarceva combined with gemcitabine group survived for more than 10 years, while only % in the control group
'r ', () Tarceva combined with gemcitabine in the treatment of progressive pancreatic cancer Cancer, can significantly prolong survival compared with gemcitabine monotherapy (%)
'r ', () The safety of the Tarceva + gemcitabine combination regimen has also been confirmed in other similar studies.
'r ', the ingredients of Tarceva
'r ', each tablet contains erlotinib (in the form of erlotinib hydrochloride).
'r ', the properties of Tarceva
'r ', round, biconvex, blue coated tablets.
'r ', Tarceva's mechanism of action
'r ', its anti-tumor mechanism is mainly to inhibit the intracellular phosphorylation of epidermal growth factor (R) tyrosine kinase.
'r ', Pharmacokinetics of Tarceva
'r ', Tarceva is % absorbed after oral administration, with a half-life of about hours and is mainly eliminated by metabolism. The bioavailability of r after oral administration is approximately %, and peak plasma concentration is reached after several hours. There is no significant relationship between the patient's age, weight, and gender and the drug clearance rate, but smoking can increase the drug clearance rate by %.
'r ', Tarceva side effects
'r ', The most common side effects of taking Tarceva are rash and diarrhea. The median onset time of rash is days and the median onset time of diarrhea is days. The incidence rate is greater than %. Common side effects include: rash, diarrhea, decreased appetite, fatigue, difficulty breathing, cough, nausea, infection, vomiting, stomatitis, itching, dry skin, conjunctivitis, keratoconjunctivitis, and abdominal pain.
'r ', What kind of lung cancer patients choose Tarceva?
'r ', Tarceva sold in India is produced by Indian Pharmaceuticals. The application situations of Tarceva in India and Iressa in India are similar. Under normal circumstances, lung cancer can be treated with Iressa or Tarceva at the same time. So how do patients choose that?
'r ', () If the patient is female, it is recommended to start taking Iressa.
'r ', () If you are a male, it is recommended to start taking Tarceva.
'r ', the above selection is mainly due to the characteristics of Tarceva and Iressa.
'r ', Clinical experience shows that Iressa is suitable for lung adenocarcinoma in Oriental women who do not smoke or have no smoking history, and the overall effective rate is as high as %. Tarceva is widely used in the treatment of lung adenocarcinoma, lung squamous cell carcinoma and non-small cell lung cancer. Therefore, for many patients taking Iressa for a long time, Tarceva can also be used as an option after Iressa resistance.
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