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Phenacetin number
Chinese synonyms phenacetin acetyl ethoxy aniline p-acetyl ethoxy aniline
English name
English synonyms
Molecular weight
No.
Chemical properties: white shiny scaly crystals or white crystalline powder. Melting point °C, refractive index
Quality standards issued by the Ministry of Standards or the British Pharmacopoeia version
Uses: Antipyretic and analgesic, used to treat fever, headache, neuralgia, etc. The antipyretic and analgesic effects of phenacetin are similar to those of acetylsalicylic acid. It is mainly used as an antipyretic and analgesic with slow and long-lasting effects. It is effective in treating headaches, neuralgia, joint pain and fever, but it is anti-rheumatic. The anti-inflammatory effect is weak. Excessive dosage can lead to methemoglobinemia and cause hypoxia in the body. Long-term use can damage the kidneys and even cause necrosis, so it should be used with caution. Due to its toxic and side effects and the rapid development of other similar drugs, this drug has stopped being used alone and is only used as a raw material drug and compound preparations with other drugs.
Preparation method Phenacetin can be synthesized by refluxing acetaminophen and ethyl iodide in the presence of anhydrous potassium carbonate in butanone. The crude product was purified by recrystallization in water.
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