Year1
- 规格：
- 100mg*30
[Common name] Sapropterin Hydrochloride Tablets
[Trade name] Kewang
[English name]
[Chinese Pinyin]
[Ingredients] Sapropterin hydrochloride
[Characteristics] Kewang is an off-white to light yellow soluble tablet.
[Indications] Kewang is suitable for hyperphenylalaninemia caused by tetrahydrobiopterin deficiency that responds to Kewang treatment. It can be used for children aged and above. Kewang does not have sufficient clinical experience in using children under 10 years old. If it must be used, it must be used with caution under the strict guidance of a specialist.
[Usage and Dosage] Kewang must be used under the guidance of a physician with experience in treating deficiencies and supervise the treatment process. A single dose of COVANT should be taken with a meal and at the same time each day, preferably in the morning.
While taking Kewang, you need to actively control the intake of phenylalanine and total protein in the diet to ensure effective control of blood phenylalanine concentration and
nutritional balance.
Deficiency causes a chronic disease. Once it is confirmed that it responds to Kewang treatment, long-term use should be planned. However, the data on long-term use of Kewang
are currently limited.
Dosage of Kewang is tablets. Calculate the daily dose based on body weight and round to a multiple of . For example, a calculated dose of
should be rounded to the equivalent of tablets. The calculated dose should be rounded to the equivalent of tablets.
When the dosage is lower than the dosage prescribed by the doctor, the tablets should be dissolved in water and then a corresponding volume of the solution should be taken according to the dosage prescribed by the doctor
. Solutions should be measured using an accurate device with appropriate graduations to ensure that the solution volume corresponds to the prescribed volume.
The starting dose for children and children with deficiencies is/body weight, once daily. Dosage adjustments can be made up to day. The total daily dose can also be divided into three or more doses per day as needed to optimize the therapeutic effect.
The most important thing to determine the response is to start Kewang treatment as early as possible to avoid the occurrence of neurological diseases in children due to the continued increase in blood phenylalanine
Irreversible cognitive dysfunction and mental illness clinical manifestations.
According to the decrease of phenylalanine in the blood, it can be judged whether it is responding to Kewang treatment. Blood phenylalanine concentrations should be measured prior to initiating treatment with COVANT and after
weeks of treatment at the recommended starting dose. If an unsatisfactory decrease in blood phenylalanine concentration is observed, the dose of COVANT can be increased weekly to the maximum
dose days and continued monitoring of blood phenylalanine concentration weekly for another month. During this period, dietary intake of phenylalanine should be maintained at a
constant level.
A good response is defined as a decrease in the blood phenylalanine concentration, or reaching the therapeutic blood phenylalanine target value determined by the attending physician based on the patient's individual conditions. If the patient still cannot meet the above standards after several months of treatment, it should be considered ineffective and should not continue to receive Kewang treatment.
Once there is a real response to Kewang treatment, the dose can be adjusted within a day based on the therapeutic effect.
It is recommended to measure blood phenylalanine and tyrosine concentrations weekly after each dose adjustment, and to monitor frequently thereafter. Patients receiving Kewang treatment must continue to adopt a phenylalanine-restricted diet and undergo regular clinical evaluations such as monitoring blood phenylalanine and tyrosine concentrations, nutrient intake, and Psychomotor development.
How to take: A single daily dose of Kewang should be taken with a meal to promote absorption. Take it at the same time every day, preferably in the morning. Patients should be instructed
to be careful not to swallow the dehumidifying capsules in the vial. Prescription tablets of COVANT should be placed in a glass of water and stirred until the tablets dissolve. Dissolution may take
several minutes. Crush the tablets to speed up dissolution. Small particles may be seen in the solution, but this will not affect the efficacy of Kewang. Liquid medicine? Drink it within minutes
.
The prescribed number of tablets of Kewang should be taken and consumed within minutes.
The prescribed number of tablets of Kewang should be placed in a cup of water, stir until the tablets are dissolved, and then taken.
Children should put the prescribed number of tablets of Kewang into a cup filled with water, stir until the tablets dissolve, and then take it.
Kewang treatment can only be stopped under the guidance of a physician. Blood phenylalanine concentrations may increase after discontinuation of the drug, requiring more frequent monitoring
. Dietary modifications are required to maintain blood phenylalanine concentrations within the ideal therapeutic range.
[Specifications] *Pieces/box
[Price] Yuan/box
[Storage] Sealed, protected from moisture and stored below.
【Validity period】months.
[Approval number]
[Manufacturer] United States
[Warm reminder] Product content and pictures are for customer reference only. Please follow the doctor's guidance for actual diagnosis and medication! Please note that our company strictly follows the Strictly control the quality
At the same time, the price of medicines is reduced to the lowest, so that the majority of patients can get real benefits, truly benefiting the people, and the price is affordable
! Ordering phone contact Mr. Gu Minyou
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