Disease Animal Models Genio Biotechnology

Guangzhou Genio Biotechnology Co., Ltd. is committed to technology research and development and the sales of biological reagents in the field of biomedicine. It specializes in providing various types of cells, factors, antibodies, fetal bovine serum and culture media and other biological reagents required for experiments. The main source of cells, etc., and also provides various technical services, overall subject paper () services, etc. Huang Sheng: -,
As time goes by, the course of the disease is not static, and in-depth exploration of the mechanism of disease cannot be completed quickly using people themselves as the research object. Therefore, using indirect research on animal models to reproduce the disease in animals can help to understand the occurrence and development of the disease more conveniently and effectively. Our company provides a fast and convenient experimental condition for the majority of scientific research units and researchers, and provides experimental animal modeling services related to various diseases, especially animal models of transplanted tumor diseases. Scientific researchers and institutions are welcome to call us to inquire about relevant experimental matters.
Part 1 Animal Model of Disease
1. Tumor animal models
According to the preparation method or source of tumor animal models, they are divided into three major categories

Spontaneous tumor animal models
Advantages: The pathogenesis and mechanism are closer to humans. Disadvantages: The quantity and type are very limited and cannot meet the needs of experiments.

Induced tumor animal model
Advantages: The pathogenesis and mechanisms are also closer to humans. Disadvantages: Almost all inducers are highly toxic to the human body, posing greater risks to experimenters. The experiment cycle is very long, and the time for successful induction is inconsistent, making it impossible to conduct large-scale experiments under the same conditions.
3
Transplantation tumor animal model
Advantages: It can be transplanted in large quantities under the same conditions, the experimental period is short, and the treatment mechanism of animals is similar to that of humans. It has become the most widely used model at present. Extensive modeling methods.
Model type
Transplantation site
Cell type
Lung cancer
Lung
Subcutaneous

Pancreatic cancer
Pancreas
/> Spleen
Subcutaneous

Colon cancer
Colon wall
Subcutaneous

Liver cancer
Portal vein
Liver
Subcutaneous

Gastric cancer
Gastric body
Subcutaneous
Abdominal cavity

Rectal cancer
Rectal wall
Subcutaneous< br/>
Breast cancer
Breast gland
Subcutaneous

Kidney cancer
Renal parenchyma
Renal capsule
Subcutaneous

Bladder cancer
Bladder wall
Subcutaneous

Melanoma
Subcutaneous

Multiple myeloma
Bone marrow cavity
Intravascular
Subcutaneous


2. Other disease animal models
Types of models

Diabetes
Spontaneous
Diseases that occur naturally in animals, are similar to certain human diseases, or are cultivated through genetic breeding And the diseased animals remain. /Mice are derived from inbred strains with autosomal recessive inheritance and are a model of type 2 diabetes. One month later, he started to overeat and gain weight, followed by hyperglycemia, hyperinsulinemia, and elevated glucagon.
Inducible
Chemical drugs are used to specifically destroy pancreatic islet cells. The most commonly used drugs are streptozotocin and alloxan, which are stable and rapid in modeling.
Liver damage
The liver damage caused mainly includes chemical liver damage, drug-induced liver damage, immune liver damage and alcoholic liver damage. Its clinical manifestations are liver necrosis, fatty liver, and liver fibrosis. cirrhosis, liver cancer, etc.
.Commonly used chemical hepatotoxic substances include carbon tetrachloride ( ), galactosamine, thioacetamide, aflatoxin, etc.
. Medicinal acetaminophen, isoniazid, cyclosporine, tetracycline and tripterygium wilfordii, etc.
. Immune BCG plus lipopolysaccharide induction method, concanavalin induction method.
. Excessive drinking of alcoholic animals can cause varying degrees of damage to the liver. In mild cases, it can develop into fatty liver and liver fibrosis, and in severe cases, it can develop into cirrhosis or hepatocellular carcinoma.
Fatty Liver
Fatty liver has become a high-risk disease in China. The incidence rate among the general population is about 10%, and it has been increasing year by year. The most commonly used method at present is high-fat diet, which is simple, reproducible, cheap, has low animal mortality and has a high replication rate.
Hepatitis B
The genome is injected into the nucleus through microinjection to establish transgenic mice that can be stably replicated and expressed in the serum. It can be used to carry out research on antiviral drugs and the pathogenesis of hepatitis B.
Spinal Cord Injury
Spinal Cord Injury is a disease with a high disability rate, which brings a heavy burden to families and society. With the rapid development of industry, construction and transportation, the number of patients with spinal cord injuries is increasing year by year. Commonly used modeling methods include the following
.
Spinal cord impact injury model
.
Spinal cord compression injury model
.
Spinal cord transection injury
.
Spinal cord traction injury model
.
Spinal cord ischemic injury

Stroke
Stroke is also known as cerebrovascular accident and is the most common in the world. One of the most important fatal diseases in the world. Diseases with cerebral ischemia and hemorrhagic injury symptoms as the main clinical manifestations have extremely high mortality and disability rates. They are mainly divided into hemorrhagic stroke and ischemic stroke, with cerebral infarction being the most common.
. br/>Hemorrhagic
Autologous blood injection method, spontaneous, collagenase injection method