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( / () [Usage and Dosage] Recommended dosage: The recommended dosage of Nexavar (sorafenib) is once. (.), twice a day, on an empty stomach or with a low-fat or medium-fat diet.
( / () Instructions for use: Take orally, swallow with a glass of warm water. The treatment time should be continued until the patient can no longer benefit clinically or an intolerable toxic reaction occurs. Dosage adjustment and special instructions for use include suspension or treatment of suspected adverse reactions. Reduce the dosage of Nexavar (Sorafenib), if necessary, reduce the dosage of Nexavar (Sorafenib) to once a day or once every other day, each time. (.).
( / () According to the skin Toxicity, dose adjustment should be made accordingly
(/) Grade skin adverse reactions such as paralysis, hypoesthesia, paresthesia, numbness, painless swelling, erythema of hands and feet or discomfort that does not affect daily activities are recommended at any time. The dose is adjusted to continue using this product, and local treatment is given to eliminate symptoms.
Grade ( / () skin adverse reactions are accompanied by painful erythema and swelling of the hands and feet, and/or discomfort in the hands and feet that affects daily life. When it first appears, Then the dose is adjusted to continue using this product, and local treatment is given to eliminate the symptoms. If the symptoms do not improve within days or appear for the second or third time, interrupt the treatment with this product until the toxicity is relieved to grade 1. When restarting the treatment with this product When it occurs, reduce to a single dose (daily or every other day). When it occurs for the fourth time, treatment with this product should be terminated.
( / () grade skin adverse reactions: desquamation, ulcers, blistering on hands and feet , pain, or severe hand and foot discomfort that causes the patient to be unable to work and live a normal life. When it occurs for the first or second time, treatment with this product should be interrupted until the toxicity is relieved to grade 1. When treatment with this product is restarted, reduce to a single dose (Daily. or every other day.). When it occurs for the third time, treatment with this product should be terminated.
( / () There is no safety and safety profile of Nexavar (sorafenib) in pediatric patients. Efficacy data. Geriatric (years and older) Gender and weight No dosage adjustment is required based on the patient's age (years and older), gender, or weight.
( / () Patients with hepatic impairment Patients with mild to moderate hepatic impairment ( and ) No dosage adjustment is required. Nexavar (sorafenib) has not been studied in patients with severe hepatic impairment.
( / () Renal Impairment Patients No dosage adjustment is required in patients with mild to moderate renal impairment. No studies have been conducted. A study of sorafenib in patients with severe renal impairment or on dialysis.