Product Details
!: : ) [Dosage]
< b : !: : ) The recommended dose of sorafenib for the treatment of renal cell carcinoma is one tablet, three times a day. Take on an empty stomach or with a low-fat or medium-fat diet.
< b : !: : ) Medication for special populations:
< b : !: : ) Children: There is no data on the safety and effectiveness of sorafenib in pediatric patients.
< b : !: : ) Elderly: No dosage adjustment is required based on the patient's age, sex, or weight.
< b : !: : ) Patients with hepatic impairment: No dose adjustment is required in patients with mild to moderate hepatic impairment. Sorafenib has not been studied in patients with severe hepatic impairment.
< b : !: : ) Patients with Renal Impairment: No dose adjustment is required in patients with mild and moderate renal impairment. There are no studies of sorafenib in patients with severe renal impairment or on dialysis.
< b : !: : ) [Adverse Reactions]
< b : !: : ) In clinical trials, the most common treatment-related adverse events include diarrhea, rash, desquamation, fatigue, Skin reactions on the hands and feet, hair loss, nausea, vomiting, itching, high blood pressure, and loss of appetite. If patients experience adverse drug reactions, they should contact their doctor in time for corresponding treatment. The dose of sorafenib can be reduced to once daily or every other day.
< b : !: : ) [Precautions]
< b : !: : ) There is still a lack of sufficient clinical research data on the Chinese population, so it must be used under the guidance of a doctor who has experience in using this product.
< b : !: : ) Skin toxicity: Hand-foot syndrome and rash are the most common adverse reactions of sorafenib. Rashes and hand-foot syndrome are usually severe and occur more frequently within a few weeks of starting sorafenib. Management of cutaneous toxic reactions includes topical administration to reduce symptoms, temporary discontinuation of the drug, or dose adjustment of sorafenib. Permanent discontinuation of sorafenib may be necessary in patients with severe skin toxicity and prolonged reactions. Severe hand-foot syndrome should permanently discontinue the drug.
< b : !: : ) Bleeding: The chance of bleeding may increase after treatment with sorafenib. Severe bleeding is uncommon. Once bleeding requires treatment, it is recommended to consider permanently discontinuing sorafenib.
< b : !: : ) Warfarin: Some patients taking sorafenib and warfarin concurrently may experience occasional bleeding or increased international normalized ratio of coagulation time. Patients taking concomitant warfarin should routinely monitor coagulation time, R value, and pay attention to clinical signs of bleeding.
< b : !: : ) Wound healing complications: The effects of taking sorafenib on wound healing have not been specifically studied. Patients who require major surgery are advised to suspend sorafenib. There is limited clinical experience in when to re-apply sorafenib to patients after surgery. Therefore, clinical considerations should be made before deciding to use sorafenib again to ensure wound healing
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