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Tarceva must be used under the guidance of doctors who have experience in using such drugs, and can only be used in the national clinical trial pharmacology base or tertiary A hospitals. The recommended dose of erlotinib monotherapy for non-small cell lung cancer is /day, taken at least one hour before or one hour after eating. Continue treatment until disease progression or intolerable toxicity occurs. There is no evidence that patients benefit from continuing treatment after progression.
Dose adjustment In patients with new acute attacks or progressive pulmonary symptoms, such as dyspnea, cough and fever, erlotinib treatment should be suspended for diagnostic evaluation. If interstitial lung disease is confirmed, erlotinib should be discontinued and appropriate treatment given. Diarrhea is usually controlled with loperamide. Patients with severe diarrhea who are refractory to loperamide or who become dehydrated require dose reduction and temporary discontinuation of treatment. Patients with severe skin reactions may also require dose reduction and temporary discontinuation of treatment. If dose reduction is necessary, erlotinib should be reduced each time.
Concomitant use of strong inhibitors such as atazanavir, clarithromycin, indinavir, itraconazole, conazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, dimethoate Dose reduction should be considered when using drugs such as ampicillin and voriconazole, otherwise serious adverse events may occur.
Using the induction agent rifampicin before treatment can reduce the effect of erlotinib. Alternative treatments without induction activity should be considered. If alternative treatments are not available, higher doses of erlotinib should be considered. If the dose of erlotinib is increased, the dose should be reduced when rifampicin or other inducers are discontinued. Other inducers include, but are not limited to, rifabutin, rifapentine, phenytoin, carbamazepine, phenobarbital, and St. John's wort, and these should also be avoided if possible. Erlotinib is eliminated by hepatic metabolism and biliary secretion. Erlotinib should therefore be used with caution in patients with liver dysfunction. If serious adverse reactions occur, erlotinib dose reduction or suspension should be considered. ,, br,, Among the latest oral targeted therapy drugs for non-small cell lung cancer, clinical studies have confirmed that it is the only targeted therapy drug that can significantly prolong the survival of lung cancer patients. Tarceva's mode of action is different from that of chemotherapy. It is a targeted therapy drug that can specifically target tumor cells and inhibit the formation and growth of tumors. It is a small molecule compound that can inhibit the signaling pathway of human epidermal growth factor receptor R. It is a key component of epidermal growth factor, also known as R signaling pathway, and plays a role in the formation and growth of various tumor cells. important role. Tarceva inhibits tumor growth by inhibiting the activity of tyrosine kinase, which is one of the important components in R cells.
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,, br ,,Tarceva is a small molecule compound that can inhibit the signaling pathway of human epidermal growth factor receptor R. Epidermal growth factor is also called R signal. Key components of the conduction pathway play an important role in the formation and growth of various tumor cells. Tarceva inhibits tumor growth by inhibiting the activity of tyrosine kinases, thereby achieving the treatment of lung cancer.
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,, br ,,What is the mechanism of action of Tarceva? Tarceva's mode of action is different from that of chemotherapy. It is a targeted therapy drug that can specifically target tumor cells and inhibit the formation and growth of tumors. It is a small molecule compound that can inhibit the signaling pathway of human epidermal growth factor receptor R. It is a key component of epidermal growth factor, also known as R signaling pathway, and plays a role in the formation and growth of various tumor cells. important role. Tarceva inhibits tumor growth by inhibiting the activity of tyrosine kinase, which is one of the important components in R cells.
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,, br ,,Tarceva is a small molecule oral epidermal growth factor receptor tyrosine kinase inhibitor with higher affinity to the target and stronger specificity , and in a large randomized phase III clinical study BR. It has been proven that as a second/third-line treatment, it can significantly prolong the survival of various types of patients. Currently, Tarceva has been approved for advanced second-line/third-line treatment in more than 10 countries around the world.
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,, br ,,So, what is the price of Tarceva? When it comes to the price of Tarceva in India, the price of Roche Tarceva as a genuine product is definitely high. Of course, as an original research manufacturer, it is understandable that it has paid huge R&D expenses. It is also sold in Hong Kong at NT$/piece for one month's usage. It costs HKD, but the discounted price is about the same. At present, it seems that Roche Tarceva can also apply for free medicines from the China Charity Federation, but you must first purchase Roche medicines for more than six months.