India direct mail Nexavar Jiangsu purchasing agent 13501239552 How much is a box of Nexavar

br r When mentioning India, many people still have an impression of dirty streets and weak infrastructure. Few people would have thought that it is not only the world’s pharmacy but also one of the most popular medical tourism destinations in the world.
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The brother of netizen Dahai, who lives in Yantai, Shandong, suffers from stromal tumor. When being interviewed by a reporter from Global magazine, Dahai had been helping his brother purchase the Indian version of Gleevec in an online store for several years. RMB per box
The original version of Gleevec from Novartis Pharmaceuticals is sold in China for more than 10,000 yuan, and all physical examination indicators have met the standards over the years. We don’t know if what we bought is real or fake, we can only say that we bought it to eat and see.
br r Cheap generic drugs are not only very attractive to developing countries. In fact, more than half of India's exported generic drugs are exported to developed countries in the United States, Europe and Japan, among which the generic drugs in the US market recently come from India.
br r What are generic drugs? Why are generic drugs so cheap? Why are generic drugs so popular in India?
br r The average price is only for patented drugs~
br r What are generic drugs? Let’s first talk about what an original drug is. The popular international name for an original drug is a brand drug, which refers to the brand name of the company that was the first to develop a certain drug in the world. Before the original drug is put on the market, it generally needs to undergo strict animal experiments, phase one, phase two and phase three human clinical trials, and then phase four clinical amplification experiments can prove that the efficacy is accurate, safe and reliable before it can be promoted to the market.
br r Generic drugs originated in the United States. In 2016, the patents of some commonly used drugs in the United States expired. Big pharmaceutical companies considered it unprofitable and were unwilling to continue development. Therefore, the United States introduced a bill
, new manufacturers only need to prove that their products have equivalent biological activity to the original drug before they can imitate it. This is how the concept of generic drugs emerged, and was later adopted by Europe and Japan.
To put it simply, generic drugs mean that drug manufacturers wait for the patent period of a certain drug from a large international company to pass before copying and selling the drug.
br r Compared with patented drugs, generic drugs are exactly the same in terms of dosage, safety, efficacy, quality, and indications, but the average price is only ~ that of patented drugs, and the difference is even more than 100% for some varieties.
br r After the reporter went to work in India, domestic friends would ask about various anti-cancer generic drugs produced in India every now and then, and hoped to buy them from India. Among them, the most frequently asked questions were about the generic drugs produced by Indian companies. Ressa and Nexavar. In the Indian market, both drugs are much cheaper than the original drugs in the domestic market.
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Iressa is a patented product of the British pharmaceutical company AstraZeneca. The company is only copying the Iressa drug license authorized by the Indian authorities. Since it uses the same drug as AstraZeneca Ingredients and production process
The price of the printed version of Iressa of the same dosage is only one-eighth of the price of the British version, which makes generic Iressa the darling of the market and one of the main sources of the company's profits. .
br r In March, it was announced that the upcoming generic hepatitis C drug tablets would be priced at rupees or about RMB, which may sound a bit expensive, but compared with the US$10,000 price of patented drugs in the United States, it is just a drop in the bucket. dish.
br r Produces global generic drugs
br r The production cost of Indian pharmaceutical factories approved by the United States is lower than that of the United States and lower than that of Europe. It is precisely by virtue of low-cost manufacturing, strong technology, a large number of qualified technical personnel who understand English and high-quality products that Indian pharmaceutical manufacturers have always been able to obtain a large number of outsourced production contracts.
br r Currently, there are a total of certified pharmaceutical factories in India, which can export about 10 types of approved drugs and pharmaceutical raw materials to the United States. There are also several pharmaceutical factories certified by the British Medicines Agency.
br r The company's performance is a microcosm of Indian pharmaceutical companies. Although relying on cheap drugs to defeat Western countries' products and sell them to overseas markets has been criticized, India itself has benefited greatly. In Indian words, the Indian pharmaceutical industry is becoming the world's pharmacy at affordable prices.
br r As the world's third largest producer of generic drugs, the average growth rate of India's pharmaceutical industry in the past year has been around 10%. India has produced the world's largest number of generic drugs and has made the pharmaceutical industry one of the pillars of the Indian economy. Currently, Indian medicines are exported to many countries, and vaccines and biopharmaceutical products are exported to more than 100 countries.
br r Around the year, many patented drugs will expire one after another. Many professional institutions predicted a few years ago that this will greatly stimulate the production of Indian generic drugs. By then, Indian generic drugs are expected to dominate the global generic drug market. The share of the Indian pharmaceutical industry will increase from the current to 100 million US dollars, and the turnover of the Indian pharmaceutical industry will increase from the current approximately 100 million US dollars to 100 million US dollars.
br r The government protects imitations
br r In fact, Indian medicines have not always been so cheap.
br r At the beginning of independence, India's pharmaceutical market was controlled by multinational pharmaceutical companies, and most of the patented drugs were in the hands of these companies. In the last century, the Indian market was famous for its high drug prices.
br r In order to allow Indians to enjoy affordable medicines, the government has taken many measures, but what really benefited Indian pharmaceutical companies was the revision of the Patent Act in 2006 under the leadership of Prime Minister Indira Gandhi.
br r The revised Patent Law stipulates that only process patents are granted for food and medicine, and no product patents are granted. This means that India has given up the protection of intellectual property rights for pharmaceutical compounds. The loose system allows domestic companies to A large number of generic drug production licenses have been obtained, thus providing space for rapid expansion of Indian generic drugs.
br r In 2009, India revised the Patent Law in accordance with the intellectual property agreement reached with the World Trade Organization. However, the new bill only provided for new drugs invented after 2008 or drugs that have been improved to significantly improve their efficacy. Patent protection does not support patents on mixtures of original drugs or derivative drugs.
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On January 1, 2020, the Supreme Court of India rejected the Swiss pharmaceutical giant Novartis’s request for patent protection of the improved new anti-cancer drug Gleevec and determined that India’s generic version of the specific drug can continue to be sold. This lawsuit lasted for more than a year.
It was the first pharmaceutical patent lawsuit that India encountered after the expiration of the transition period of the relevant intellectual property agreement. It involved major issues such as how to implement patent protection clauses, and also related to whether developing countries can continue to Access to lower-priced drugs, while India's Supreme Court's final judgment provides an umbrella for the country's generic drug industry.
br r Over the years, the Indian government has also been supporting the development of generic drugs through various methods such as the loan industry partnership program. At the same time, the government uses loosening and tightening policies to guide companies to produce high-quality drugs and to eliminate illegal generic drugs.
br r Why is it so fast?
br r In 2018, India’s new patent law officially came into effect. This was a landmark event in the Indian pharmaceutical industry. This policy was seen by many as a tightening. According to the new patent law, Indian companies cannot continue to use it for many years. It has been a common practice to ignore the patents of multinational companies and produce their own imitations of pharmaceutical products.
br r After the new patent law came into effect, India focused on cooperating with international giants to occupy the market. For example, in order to control the US$100 million insulin market when a large number of anti-diabetic drugs lost patent protection, Bazong Company in Bangalore, India, cooperated with Pfizer. The insulin mimetic products produced by the company, recombinant human insulin glargine, insulin aspart and insulin lispro, were launched in India in 2011.
br r Bo Cong also acquired an American intellectual property company. br Through the merger, the company not only has the ownership of oral insulin and oral cerebropeptide for the treatment of cardiovascular diseases, but also has valuable knowledge. Property rights platform.
br r Although
the new patent law is seen by Indians as a tightening of the government's policy on generic drugs, it is still very loose in the eyes of the outside world. According to regulations, drugs approved for marketing in the United States do not need to undergo clinical trials when they are marketed in India
As long as the Indian pharmaceutical factory can make the same product as the drug marketed in the United States, and the two products are tested and certified by the Drug Administration of India Once the ingredients are consistent, the medicine can be legally marketed in India.
br r The strengthening of R&D capabilities and the loosening of policies have enabled Indian pharmaceutical companies to copy drugs very quickly. A few months after a new drug is launched in the United States, similar Indian generic drugs can be produced and enter the Indian market. And the same drug may be produced by multiple Indian pharmaceutical factories.
br r For example, for the specific drug for hepatitis C recently launched in India, there are no fewer Indian manufacturers licensed to produce generic drugs. The emergence of a large number of generic drugs has driven down drug prices. Under this situation, it is difficult for manufacturers who are not first-hand producers of generic drugs to make profits. This objectively basically eliminates the emergence of fake generic drugs or inferior ingredients with substandard ingredients. medicine.
br r The United States and Europe are attacking India
br r Perhaps it is because the development trend of the Indian pharmaceutical industry is too fierce, which has touched the cake of many people. Although India claims to have adopted a strict regulatory model for the pharmaceutical industry, in the past two years, many pharmaceutical factories in India have frequently encountered red card warnings from the United States and Europe due to quality management issues, and countries such as Vietnam have also threatened to ban Indian drugs.
br r According to the British "Financial Times" report, in January 2019, the Israeli generic drug company Teva Pharmaceuticals recalled nearly 10,000 bottles of drugs produced by its Indian supplier R Company because they did not meet production quality standards.
br r The company is not the only Indian company that has encountered US supervision. So far, an Indian pharmaceutical company has been blacklisted. The direct consequence of this is that the pharmaceutical bases in India that had been approved for export to the United States were owned by different companies and lost this qualification due to regulatory issues.
br r Not only that, at the beginning of the year, the European Union Executive Committee also requested that generic drugs produced in India be suspended from sales. Behind this big move, the European Medicines Agency discovered that several Indian companies commissioned to conduct drug testing were suspected of fabricating data.
br r These cases have intensified the concerns of European and American drug regulatory authorities about the quality of imported Indian drugs.
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Although the Indian drug regulatory authorities admit that there are loopholes in India's drug supervision, many people in India attribute the problem of drug quality supervision to India's corporate culture. Most Indians are unable to recognize accurate Where the value of data lies, senior managers of enterprise production personnel generally accept lower standards. As a culture, we will accept when a product only meets 80% of standards. This is not a systemic problem in pharmaceutical technology, it is a corporate culture problem.
Said Shah, Secretary General of the Indian Pharmaceutical Federation.
br r Murali Nilakantan, a former consultant to Cipla, India's fourth largest pharmaceutical sales company, also pointed out that Indians don't like to say no or give bad news, so the test results are always good. You know what people expect the results to be, and you just act accordingly.
br r Nonetheless, Shah also said that he believes that the vast majority of large Indian pharmaceutical companies are working to solve these problems. The Quality Forum project will focus on changing the internal culture of the company in an effort to meet U.S. standards. Large pharmaceutical companies will also Provide training for pharmaceutical industry professionals in conjunction with international production standards.
br r In March 2019, the Central Drug Standard Control Organization of India and the Ministry of Health and Family Welfare of India issued a guidance plan for drug regulators with the purpose of ensuring the effectiveness, quality and safety of drugs.
br r However, it will take time to test whether the above measures can enable Indian pharmaceutical companies to successfully survive the increasingly stringent international regulatory pressure.
br r The copies of Indian generic drugs are not aliased
br r The copies of Indian generic drugs are said to be not aliased. How is this achieved? You can look at the path taken by Reddy Pharmaceuticals, India's second largest pharmaceutical company.
br r Currently, Reddy Pharmaceuticals ranks seventh in the U.S. generic drug market. At the beginning of its business, Dr. Reddy, the founder of Reddy's, developed influential analgesic drugs for the most common pain diseases in India, which gave Reddy's Pharmaceuticals the capital to establish itself in the Indian market.
br r At the same time, Reddy, who has a profound insight into medical technology, is also good at keeping up with world trends and taking advantage of the lack of compound protection in Indian patents to continuously develop global best-selling generic drugs as soon as possible.
br r In 2017, Reddy's Prozac tablets developed by Reddy's were the company's first generic drug to enter the U.S. market. This was also the first generic drug for an Indian company to enter the U.S. generic drug market. . The reason why this first generic drug was born is because of Reddy’s years of market research and development research in the United States.
br r Reddy's found that Prozac tablets are mainly available in the US market, but in clinical practice, American doctors are more accustomed to letting patients take Prozac tablets each time. To this end, Reddy's made the decision to develop products
br r With the help of this improved transplantation technology, a large number of Indian pharmaceutical companies have been able to develop, and the Indian pharmaceutical industry has become a large-scale industry.
br r In order to improve the quality of drugs, India has learned from the drug supervision methods of the United States and absorbed the practices of the American pharmaceutical industry, and has continuously promoted domestic generic drug companies to strengthen research and development and upgrade their preparation processes. At present, India's Reddy Pharmaceuticals
Sun Pharmaceuticals, Rubin Pharmaceuticals, Glenmark Pharmaceuticals and Arabindu Pharmaceuticals have developed into well-known international pharmaceutical companies, and their drugs occupy considerable market shares in the United States.
br r Attached is the Indian medicine purchased overseas, beware of fakes
br r Source: Zhou Lin, author of Global Magazine. This article was originally published in the issue of "Global" magazine published on the year, month and day
br r Zhejiang A family member of a cancer patient in Ningbo told a reporter from Global Magazine that there are generally two ways to buy Indian medicines overseas. One is to pay some overseas students in India some processing fees and let them buy them directly for you. The other is to go directly to the Internet. Indian purchasing agency on the Internet.
br r If you search for anti-cancer drugs such as Gleevec and Iressa on the Internet, you will see a lot of purchasing information, and there are dozens of groups each with hundreds of active users. In the three Gleevec exchange groups that the reporter joined, although the group rules state that direct discussion of the purchase of Yin Ge is not allowed, the most frequently asked question by users every day is whether there are any channels for selling Yin Ge
br r Overseas Purchasing Agency There are generally three types of drugs. One is that they are already on the market abroad, but not sold in China. The other is that they are already on the market at home and abroad, but they are relatively cheaper abroad due to taxes and other reasons. The third is strong imitation drugs represented by India, which are only as expensive as the original drugs. A few tenths. Liu Zhengchen, a member of the leadership committee of the International Chronic Myelogenous Leukemia Patient Conference and also a patient, told reporters.
br r If the first two categories of drugs are from legal sources, their quality is guaranteed. For the third category of drugs, due to the large number of imitation companies, the quality varies. In particular, some Indian companies fish in troubled waters and claim to be generic drugs, but the quality may be much worse, so it is difficult for patients to judge whether the medicine they finally buy is real or fake. .
br r If you encounter small pharmaceutical companies whose drugs come from abroad, it is likely that their certificates are forged. If there is a real problem, Internet purchasing agents may run very fast. The foreign language proficiency and legal consciousness and medical knowledge of patients who purchase drugs through this channel are not enough to support transnational litigation. Liu Zhengchen said.
br r The State Food and Drug Administration issued a document in March to remind consumers not to purchase anti-cancer drugs purchased overseas through the Internet. At the same time, the State Food and Drug Administration reminds consumers that anti-cancer drugs are prescription drugs. According to the Interim Provisions on the Approval of Internet Drug Transaction Services, the sale of prescription drugs on the Internet is prohibited.