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We are not experts, but I think I know a lot about lung cancer and the use of Iressa. After contacting many patients taking Iressa, plus hearing about the conditions of some patients who have not had direct contact, and gaining a detailed understanding of this drug, I have accumulated relatively rich clinical experience. At the same time, I also found that some patients and even doctors had some misunderstandings about the use of Iressa, and most of the patients' misunderstandings came directly from their doctors. Below, I will talk about a few points that are easy for people to misunderstand: <
1. The prerequisite for patients to take Iressa does not necessarily require chemotherapy before taking it. The instructions for Iressa mention that the drug is mainly suitable for the treatment of locally advanced or metastatic non-small cell lung cancer () that has previously received chemotherapy or is not suitable for chemotherapy. Literally, it does not say that if the patient needs to take Iressa, You must go through the process of chemotherapy, because some patients are not suitable for chemotherapy. From an actual clinical point of view, many patients who are older and have poor physical fitness take Iressa directly without chemotherapy. The effect is also very good and lasts for a relatively long time. From a comprehensive comparison, there is no The effect is worse than that of patients who take Iressa after undergoing chemotherapy. Therefore, patients who take Iressa do not necessarily need to undergo chemotherapy. They can take it directly without chemotherapy. Some doctors don’t know whether they misunderstood the meaning literally or did not understand it correctly during training, or it is for the benefit of the hospital that patients must undergo chemotherapy to increase the hospital’s income. I am raising this again and hope to give a reminder to those who have misunderstood it. .
2. Patients who are not smokers cannot take Iressa. Patients who are not smokers cannot take Iressa. Some people think that patients with a history of smoking are not suitable for taking Iressa, and directly recommend patients to take Tarceva. In fact, this view is wrong. First of all, there are too many cases where smoking patients are effective when taking Iressa. This is enough to show that patients with a history of smoking can also take Iressa. However, the clinical data of Iressa also shows that the effectiveness of Iressa in patients with a history of smoking is indeed lower than that in patients who do not smoke. As for the degree of effectiveness, that is, whether the effect is good or not, what can be achieved? The degree mainly depends on the individual differences of the patients, and it does not seem to have much to do with smoking, because I have also encountered patients with a history of smoking who had very good results. Secondly, the mechanisms of action of Tarceva and Iressa are similar. The drugs themselves also have many similarities, and even the possible side effects of the two are very similar. The effectiveness of Tarceva in patients with a history of smoking is also lower than in patients without a history of smoking. This is the same as Iressa. I say Tarceva is good, but I really don’t have too much clinical data to prove this point of view. To sum up, whether you have a smoking history cannot be used as a reason to absolutely rule out the use of Iressa. This is also an issue that is easily misunderstood by patients or some doctors. I suggest that it is better to moderate it, and it will definitely have better results! !
3. There is no absolute connection between the occurrence and magnitude of side effects and the effectiveness of the drug. Many doctors and patients believe that if side effects occur after taking Iressa, it means that the drug is effective for the patient, and vice versa. In fact, this view is wrong. Some patients I met who took Iressa did not have any side effects after taking the medicine, but the effect was surprisingly good. Some patients had very severe rashes after taking Iressa, with big pimples all over their face, or they had diarrhea many times a day. , almost dehydrated, but there is no effect or the effect is very average. These cases are enough to show that there is no absolute relationship between side effects and whether Iressa is effective. However, most patients have good effects while experiencing side effects. Perhaps it is because of this that some people one-sidedly believe that side effects and effects are connected. Since the individual physical characteristics of patients are different, when the side effects appear, the type, duration, and severity are exactly the same for each patient. The best way to determine whether Iressa is effective is to conduct a reexamination to see if the tumor shrinks. If the patient's symptoms are obvious, it can be intuitively judged based on whether the patient's symptoms have improved. In practice, I specifically stated that most patients with severe side effects will not have very good results. The reason is that patients with severe side effects often stop taking the medicine or reduce the dosage, and cannot take the medicine according to the dosage, so the effect is much worse.
4. The effect of Iressa is better for women than for men. This view is wrong that men are not suitable for taking Iressa. They are all Asians and Chinese, and they have to distinguish between men and women when taking medicine. First of all, it doesn't make sense. Secondly, in countless clinical practices, the effect of men taking Iressa is no worse than that of women. Among my male patients, there are not a few who take Iressa every year, and now they are like normal people. I think whether the effect of taking Iressa is good or not depends on the patient’s condition, personal physical characteristics and mentality. Some doctors tell family members of patients that men should take Tarceva if the effect of Iressa is not good. I think this is absolutely wrong, and the practical results speak for themselves.
The above are some questions that my website has personally summarized. They are for your reference only. I hope they can give you some help.
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