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Drug name:
Common name: Imatinib mesylate capsules< .
_b> English name: ( )
Trade name: Gleevec
= Ingredients:
The active ingredient of this product is imatinib mesylate. =Indications:
For the treatment of chronic phase, accelerated phase or blast phase of Philadelphia chromosome-positive chronic myelogenous leukemia (+). For the treatment of unresectable and/or metastatic malignant gastrointestinal stromal tumors ( ) for adult patients for the following indications, the safety and effectiveness information mainly comes from foreign studies... = Usage and Dosage:
Treatment should be carried out by physicians who have experience in treating patients with malignant tumors. Imatinib mesylate should be taken with a meal and a large glass of water. Typically adults take one oral dose, orally, and oral dosage is dosed three times per day (in the morning and evening)... = Adverse Reactions:
Patients with advanced malignancies may experience mixed clinical symptoms, but due to their It is related to the underlying disease, the progression of the disease itself, and the simultaneous use of multiple drugs, so it is often difficult to determine their cause and effect. Generally speaking, long-term daily oral administration of this product is less tolerable to patients, including pediatric patients...=Contraindications:
It is contraindicated for those who are allergic to the active substance of this drug or any excipient ingredients. =Precautions:
It has been reported that patients treated with this product have significant reductions in left ventricular ejection fraction (EF) and symptoms of congestive heart failure. Animal experiments have shown that -B enzyme inhibitors can cause strong reactions in cardiomyocytes. In carcinogenicity tests in rats, myocardial diseases have been reported. Therefore, for...=Drug Interactions:
Pharmaceutical inhibitors that alter imatinib plasma concentrations: Imatinib's Significant increases in drug exposure (mean maximum plasma concentration () and area under the imatinib curve () can be divided... = Toxicological studies:
After long-term treatment with imatinib, opportunistic The incidence of infection increased, and malaria infections that were normally suppressed in monkeys worsened. Genotoxicity was measured in an in vitro bacterial ( ) assay, an in vitro mammalian cell assay (mouse lymphoma assay), and an in vivo...