For chloramphenicol raw materials, please look for Wuhan Dongkanyuan Technology Co., Ltd.

Product name Chloramphenicol
It belongs to the category of antibiotics produced by Streptomyces venezuelae. It is a bacteriostatic broad-spectrum antibiotic. Sensitive bacteria include Enterobacteriaceae, Bacillus anthracis, Pneumococcus, Streptococcus, Listeria, etc.
The shape is white needle-like or slightly yellow-green needle-like, long flake crystal or crystalline powder and tastes bitter. Soluble. It is stable when dry, relatively stable in weakly acidic and neutral solutions, and does not decompose when boiled. It is easily ineffective when exposed to alkalis.
The main purpose is a broad-spectrum antibacterial antibiotic. It is the first choice drug for the treatment of typhoid fever and paratyphoid fever. It is one of the most effective drugs for the treatment of anaerobic bacterial infections. It is also used for the treatment of various infectious diseases caused by sensitive microorganisms. Due to serious adverse reactions, it is used less and less
Biochemical chloramphenicol antibiotics can act on the subunits of bacterial ribonucleosomes and hinder protein synthesis. They are bacteriostatic broad-spectrum antibiotics.
Mechanism of action Chloramphenicol is absorbed from the upper part of the intestinal tract, and the drug concentration in the blood can reach a peak (approximately) in about an hour after oral administration. Plasma/average is , and the effective plasma concentration is still maintained after ~ hours. Chloramphenicol is widely distributed in various tissues and body fluids, and the concentration in cerebrospinal fluid is higher than other antibiotics. The dissolution and absorption of chloramphenicol are related to the particle size and crystal form of the preparation. Intramuscular injection has slower absorption and lower blood concentration. It is only the same dose as oral administration, but the maintenance time is longer. Chloramphenicol for injection is the sodium salt of succinate, which has high solubility in water and is hydrolyzed in tissues to produce chloramphenicol.
Most of the metabolism of chloramphenicol in the body is combined with glucuronic acid, and its unchanged drug and metabolites are quickly excreted in the urine. The oral dose of effective unchanged drug is filtered by the glomerulus and excreted into the urine. It can reach effective antibacterial concentration and can be used to treat urinary system infections. People with poor renal function should reduce the dosage when using it.
Pharmacological properties are broad-spectrum bacteriostatic agents. It can diffuse into bacterial cells through lipid solubility, and mainly acts on the subunits of bacterial ribosomes, inhibiting transpeptidase, hindering the growth of peptide chains, inhibiting the formation of peptide chains, and thus preventing protein synthesis. At high concentrations or bacteria that are highly sensitive to this product, it also has a bactericidal effect.
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