Wuhan high-quality topiramate manufacturer direct sales and spot supply of topiramate

Topiramate number
Chinese synonyms: topiramate, topiramate, topiramate, topiramate (to treat epilepsy, bis(methylethylene) fructopyranosulfamate, bis(methylethylene)pyranose sulfamate) Frucranose sulfamate
English name
English synonyms,, ,,
Molecular formula
Molecular weight
Properties: white crystal powder, bitter taste, easily soluble in alkaline in solution.
Description: It is a natural monosaccharide, fructose dextrose sulfide, and lamotrigine vigabatrin, which is a broad-spectrum anti-epileptic drug that is currently used clinically in my country and can be used to control Different types of epilepsy have good efficacy and pharmacokinetics, but in children and when the dosage is increased quickly, it can cause cognitive impairment and neurotoxicity, and easily promote kidney stones.
Pharmacokinetics Topiramate is a white crystal powder with It has a bitter taste and is easily soluble in alkaline solutions. The saturated solution value is rapidly absorbed after oral administration and can reach an average of // in ~ hours. Food has no significant effect on the bioavailability of topiramate, and the average absorption after oral administration is approximately approximately. Topiramate with ~ The mean distribution volume of plasma protein is. When a single oral dose is given to ~, it exhibits linear drug metabolism characteristics, and patients with normal renal function can reach steady-state plasma concentrations in ~ days. Orally administered and, times daily, the average/hour is approximately 1 hour. Oral administration ~, times a day, if you take phenytoin or carbamazepine at the same time, the plasma concentrations of the latter two will increase correspondingly with the increase in dose. Therefore, these patients should pay close attention to adverse reactions and monitor the plasma concentration of the drug if necessary. And phenytoin and carbamazepine can reduce the blood concentration of topiramate, so the drug dosage needs to be adjusted according to the efficacy and adverse reactions. Valproate does not significantly affect the plasma concentration of topiramate. Only the left and right topiramate are metabolized with the original drug. When treated with anti-epileptic drugs, the amount of topiramate is approximately Metabolized by drug enzymes. Almost all topiramate metabolites produced in the human body have no anticonvulsant activity. Prototype topiramate and its metabolites in the human body are cleared by the kidneys. Oral ~, times a day, the average renal clearance rate is about / minute, Patients with impaired renal function or liver damage have reduced plasma clearance and renal clearance, and it may take ~ days to reach steady-state plasma concentrations. Generally, there is no change in plasma clearance in elderly patients.
Use as an anticonvulsant Anti-epileptic drugs.
Packaging cardboard drum
Standard
Unit price yuan/