Supply India Gleevec for sale India Gleevec price 15101509702

Gleevec, [Indian Gleevec, Gleevec price] Contact person: Ms. Li, phone number: Product name: [Indian Gleevec] Price: Yuan
Generic name: Imatinib mesylate
English name:
Properties: [Gleevec] The chemical name of imatinib mesylate is -[(-methylpiperazine)methyl][-methyl-[[-( 3-pyridine)pyrimidine]amino]phenyl]-aniline methanesulfonate, the molecular formula is 33, the molecular weight is.
【Gleevec】The content is white to off-white powder.
Pharmacological effects: [Gleevec] can inhibit b tyrosine kinase at the cellular level both in vivo and in vitro, and can selectively inhibit b-positive cell line cells, chromosome-positive chronic myelogenous leukemia and acute lymphoblastic leukemia. The patient's fresh cells proliferate and induce apoptosis. In addition, [Gleevec] imatinib mesylate can also inhibit platelet-derived growth factor (PLGF) receptors, stem cell factor (PLGF) receptors, and tyrosine kinases of the receptors, thereby inhibiting cell behaviors mediated by and stem cell factors. . Preclinical and clinical data suggest that some patients may develop resistance through different mechanisms.
Indications [Gleevec] It is used to treat malignant gastrointestinal stromal tumors that cannot be surgically resected or metastasize in patients with chronic myelogenous leukemia () in blast phase, accelerated phase or chronic phase after failure of interferon therapy. patient.
Starting dose: [Gleevec] For patients in the blast phase and accelerated phase of chronic myelogenous leukemia, the recommended dose of [Gleevec] is/day [Gleevec] For patients in the chronic phase who have failed interferon therapy, As well as patients with malignant gastrointestinal stromal tumors that cannot be surgically removed or have metastasized, the recommended dose is/day, which is taken orally once a day. It is advisable to take the medicine with a meal and drink a large glass of water. As long as it is effective, it should be continued. .
If the blood picture permits and there are no serious adverse drug reactions, the dose of [Gleevec] may be considered to be increased from /day to /day, or from /day to /day (, divided into doses) under the following circumstances: Disease Progress, failure to obtain satisfactory hematological response after at least 3 months of treatment, and the hematological response that has been achieved disappears again.
The dose must be adjusted in the following circumstances: If serious non-hematological adverse reactions (such as severe water retention) occur during treatment, the drug should be discontinued until the adverse reactions disappear, and then the dose will be adjusted according to the severity of the adverse reactions.
Adjustment of dosage in case of severe liver toxicity: If the increase in bilirubin exceeds 3 times the upper limit of the normal range or the increase in transaminases exceeds the upper limit of the normal range, the drug should be discontinued until the above indicators drop to the upper limit of the normal range respectively. Or . times or less.
Dose adjustment in neutropenia or thrombocytopenia: Acceleration phase or blast phase: If severe neutrophils and thrombocytopenia (neutrophils/and/or platelets/) occur, it is recommended that the dose be reduced to / day. If the blood cells continue to decrease for weeks, the dose should be further reduced to / day. If the blood cells continue to decrease for weeks, it is advisable to stop the drug until neutrophils (r) ./ and platelets (r) /. When used again, the dose is / day .
Indian Gleevec should be stored for less than 3 years. Manufacturer: Indian Pharmaceuticals Co., Ltd.
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