Ginsenoside Rh2 in the treatment of ovarian cancer

Ovarian cancer is one of the most common tumors in women. Ovarian cancer is the leading cause of death among all types of gynecological tumors, posing a serious threat to women's lives. Its five-year survival rate is only

~

. According to epidemiological statistics, women who are susceptible to ovarian cancer include those with ovarian insufficiency, such as those with delayed menarche, early menopause, dysmenorrhea, singleness, infertility, frequent induced abortions, and those with a family history. Since the ovaries are located deep in the pelvic cavity, there may be no or mild symptoms in the early stages of the disease, manifested as a mass in the uterine appendage, accompanied by unexplained gastrointestinal symptoms, such as loss of appetite, abdominal distension, and weight loss

As the disease progresses, different symptoms may appear, mainly including lower abdominal distension, abdominal distension and intra-abdominal masses, pain or irregular uterine bleeding, etc.
. Because the early clinical symptoms of ovarian cancer are very inconspicuous, it is very difficult to identify the type of tissue and judge benign and malignant. During laparotomy for ovarian cancer, only 0% of the tumors are found to be localized in the ovary
, and most of them have spread to the ovary. The uterus has bilateral attachments, the omentum and various pelvic organs, so ovarian cancer is a big problem in both diagnosis and treatment.
. Over the years, experts have invested a lot of energy in clinical research on ovarian cancer, trying to find high-efficiency and low-toxic anti-ovarian cancer drugs. Ginseng is a valuable traditional Chinese medicine that has been studied much since ancient times. Modern medical research shows that ginseng has various biological activities such as anti-tumor and anti-radiation. Its main active ingredient is ginsenosides. Combined with advanced extraction and separation technology, more than 10 saponins have been isolated from ginseng and their structures have been determined. By comparing the anti-tumor effects of various ginsenosides, it was found that ginsenoside Rh
inhibits the proliferation of cancer cells. It has the strongest effect and is the main anti-cancer active ingredient in ginsenosides. Ginsenoside Rh
is effective against a variety of tumors by inhibiting cancer cell proliferation and inducing cancer cell differentiation and apoptosis, and also provides a new weapon for the treatment of ovarian cancer.
. Zhu Junrong, Sun Jianguo and others studied the effect of ginsenoside Rh
on the proliferation and apoptosis of estrogen-dependent human ovarian cancer cells
. The results showed that
the growth of cells was inhibited after the action of Rh
in a dose-dependent and time-dependent manner. The half inhibitory concentration was/
Optical microscopy showed that
the cells were inhibited by Rh
After the action, there were obvious morphological changes of apoptosis
Flow cytometry test confirmed that Rh
can induce
apoptosis within a certain concentration range and block the cell cycle in
period, and increase
expression. It shows that Rh can inhibit cell proliferation and induce apoptosis, and is effective against ovarian cancer.
. At the same time, multiple clinical experiments have shown that
ginsenoside Rh
in the saponins of the ginsenoside group is effective against cervical cancer, pancreatic cancer, nasopharyngeal cancer, colon cancer, rectal cancer, lung cancer, and liver cancer. , breast cancer, gastric cancer, esophageal cancer, uterine cancer, leukemia and other types of cancer have significant effects.
. Ginsenoside Rh
also has good safety. Gao Feng and others from Jilin Ginseng Research Institute have confirmed through experiments that ginsenoside Rh
has an effect on the nervous system and respiratory system of normal mice and dogs. , no significant impact on the cardiovascular system, which is significantly different from other anti-cancer chemotherapy drugs.
. Because of the high efficiency and low toxicity of ginsenoside Rh
, it can kill tumor cells without damaging normal cells. It can also activate the function of immune cells to play the role of the body in clearing cancer cells, which is more beneficial to patients. Rehabilitation.
. Ginsenoside rh
Manufacturer Hu Consultant
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