Effect of ginsenoside RH2 on pain in patients with advanced cancer

&The effect of ginsenoside R on pain in patients with advanced tumors. Long-term chemotherapy will cause damage to the body. If the pain is too severe, the disease may develop further. It is recommended to check and confirm the diagnosis as soon as possible. During the analgesic process, you can follow the three-level analgesic method, start with relatively elementary analgesics, and gradually increase the dosage and upgrade. However, analgesics can easily develop drug resistance, so it is necessary to supplement some traditional Chinese medicines for relief. Modern Chinese medicines with a content of . The combined use of analgesics can enhance the analgesic effect and slow down the development of drug resistance.
Pain is the most common comorbidity in patients with advanced cancer. Continuous pain not only affects the patient's normal life, especially when the pain lasts for a long time and gradually worsens. Patients feel that life is worse than death and often lose hope of survival.
Causes of pain in patients with advanced cancer
Pain is the most common comorbidity in patients with advanced cancer. Continuous pain not only affects the patient's normal life, especially when the pain lasts for a long time and gradually worsens. Patients feel that life is worse than death and often lose hope of survival. According to the classification of tumor patients, pain can be divided into nociceptive pain, neuropathic pain and mixed pain. Pain caused by tissue damage that stimulates sensory nerves is nociceptive pain, and pain caused by damage or dysfunction in the peripheral or central nervous system that conducts pain is neuropathic pain. Advanced cancer pain often combines nociceptive pain and neuropathic pain.
Among the causes of late-stage cancer pain, tumor factors account for %, tumor treatment accounts for %, and other factors account for %. Direct factors of tumors include tumor growth, tissue destruction caused by metastasis (such as bone destruction caused by bone metastasis), tissue compression or stimulation, nerve damage, and nerve compression. Cancer patients often have low immunity, and the incidence of some painful diseases such as herpes zoster is significantly higher than that of ordinary people. These indirect factors are also one of the causes of pain in advanced cancer patients.
In addition, cancer patients may also experience pain during treatment. Chemotherapy can sometimes cause pain due to phlebitis caused by the drug, tissue damage or even necrosis caused by drug leakage. Radiation therapy may cause infection and mucosal ulceration in the treatment area, which may cause pain. Abdominal or pelvic radiation therapy can cause acute radiation enteritis in some patients, with symptoms such as spasmodic abdominal pain, nausea, and diarrhea. Some patients may have symptoms that disappear for months after stopping treatment. Some patients may even suffer lifelong pain if they do not receive active treatment. . Radiotherapy for breast cancer and esophageal cancer can cause damage to the brachial plexus, resulting in paresthesia, pain and weakness of the upper limbs. These are the main symptoms. A few can heal on their own, but most patients must undergo treatment to get relief from pain. The use of biological agents during immunotherapy may cause fever, body aches and other discomforts. Surgery causes more pain, and the incidence of neuralgia caused by intercostal nerve damage during thoracotomy is relatively high.
Among all late-stage cancer pains, some are easy to control, while others respond poorly to general pain treatments and become refractory or intractable pain. Neuropathic pain accounts for a large proportion of late-stage cancer pain. Due to the destruction of central nerves or peripheral nerves by tumors or tumor treatment, various remodeling and other changes occur in peripheral nerves or central nervous system, leading to various severe neuropathies in patients. rational pain. Because the pathophysiology of neuropathic pain is very complex, the treatment effect for general pain is not ideal. Although some neuropathic pain is very severe, no suitable control method can be found.
Late-stage cancer pain is mostly mixed pain, and the selection of drugs needs to be more careful. Nociceptive pain responds to all medical conditions in the three-step ladder of treatment. Neuropathic pain has little effect on nonsteroidal anti-inflammatory drugs, and acetaminophen has an effect on some neuropathic pain. Among the weak opioids, tramadol has a certain effect because of its biphasic analgesic effect. Strong opioids have certain short-term effects on neuropathic pain, but there is currently no clinical evidence to support their long-term effects. Some antidepressants and anticonvulsants have special effects on neuropathic pain, such as carbamazepine, gabapentin, pregabalin, etc., and have become first-line drugs for the treatment of neuropathic pain. However, these drugs also have different indications for different types of neuropathic pain. Secondly, analgesics need to be used in combination. Breakout pain caused by bone metastasis is also one of the common refractory advanced cancer pains. It is often difficult for a single analgesic drug to achieve good analgesic effects, especially in relieving breakout pain. Combination medication can control breakthrough pain in most patients. Choose non-steroidal anti-inflammatory drugs with better anti-inflammatory effects or steroidal glucocorticoids, bone metabolism regulating drugs combined with weak opioids or low-dose strong opioids. The analgesic effect is much better than that of any analgesic drug, and it can significantly reduce adverse reactions.
Long-term chemotherapy will cause damage to the body. If the pain is too severe, it may be that the condition has further developed. It is recommended to check and confirm the diagnosis as soon as possible. During the analgesic process, you can follow the three-level analgesic method, start with relatively elementary analgesics, and gradually increase the dosage and upgrade. However, analgesics can easily develop drug resistance, so it is necessary to supplement some traditional Chinese medicines for relief. Modern Chinese medicines with a content of . The combined use of analgesics can enhance the analgesic effect and slow down the development of drug resistance.
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