Ibuprofen*CAS 15687-27-1 *Yuancheng

Ibuprofen* *Yuancheng
English name
Chinese alias: ibuprofen, ibuprofen, ibuprofen, methyl (methylpropyl) phenylacetic acid (isobutylbenzene) Isobutylmethylphenylacetic acid Isobutylmethylphenylacetic acid First-class respiratory system drugs
Second-class classification antipyretic analgesics and anti-cold drugs
[Prohibited words] Classification antipyretic analgesics and other anti-cold prescriptions
Keywords ibuprofen , Ibuprofen, Isobuprofen, Fenbid
Content
Moisture
Heavy metals
Ignition residue
Particle size
Organic volatile impurities comply with Regulations
Isobutyl acetophenone
Packing specifications
Storage conditions Store in a dark, airtight, dry and ventilated place away from light. Valid for years.
Usage: Used as a synthetic enzyme inhibitor with antipyretic, analgesic and anti-inflammatory effects.
This product only has anti-inflammatory and analgesic effects in the treatment of gout, and cannot correct hyperuricemia. It is used for the treatment of rheumatoid arthritis. Its anti-inflammatory and analgesic effects are similar to those of aspirin and phenylbutazone, and better than acetaminophen. It has mild adverse effects on the gastrointestinal tract and is easily accepted by patients.
Pharmacological effects
This product is a phenylpropionic acid non-steroidal anti-inflammatory analgesic. It has strong anti-inflammatory, anti-rheumatic, antipyretic and analgesic effects, and works by inhibiting the synthesis of prostaglandins and blocking the release of inflammatory mediators. It is characterized by having no significant effect on hemogram and renal function, little gastrointestinal irritation, and no tendency for drug accumulation in the body. It is used for rheumatoid arthritis. Its anti-inflammatory, analgesic and antipyretic effects are similar to those of aspirin and phenylbutazone, and better than acetaminophen. However, it has less adverse reactions on the gastrointestinal tract and is easily accepted by patients. This product only has anti-inflammatory and analgesic effects in the treatment of gout and cannot correct hyperuricemia. It inhibits platelet adhesion and aggregation reactions and prolongs bleeding time. Its anti-inflammatory effects are equivalent to those of aspirin. For rheumatoid arthritis, this product is as effective as daily aspirin, but has fewer gastrointestinal side effects than aspirin. In the treatment of osteoarthritis, this product is as effective as indomethacin with fewer side effects.
Pharmacokinetics
Oral absorption is rapid and complete. When taken with food, the absorption slows down, but the amount of absorption does not decrease. After taking the drug, the blood drug concentration can reach the peak value, and the fluctuation of blood drug concentration is small, and there is no tendency of drug accumulation. The drug can slowly pass through the synovial cavity. After the blood concentration is reduced, it can still maintain a high concentration in the joint cavity. It can easily pass through the placenta and enter the breast milk. Its plasma protein binding rate is mainly metabolized by the liver. It is excreted by the kidneys in the urine, of which the original substance is excreted, and a small part is excreted in the feces. Very little enters the breast milk. This product can be absorbed through the rectum or skin. No accumulation.
Indications
Clinically used for rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, acute gout, mild to moderate pain (including dysmenorrhea) and fever caused by various causes. This product can be used to relieve pain and inflammation, such as sprains, strains, low back pain, frozen shoulder, bursitis, tendonitis, tenosynovitis, rheumatoid arthritis and non-rheumatoid arthritis, osteoarthritis, dysmenorrhea, toothache and Postoperative pain. Because this product has fewer side effects on the gastrointestinal tract than aspirin, it is suitable for patients who are intolerant to aspirin.