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Chinese synonyms: flumquine fluoride, dihydromethyl oxy, benzoquinazine carboxylate flumequine carboxylate (fluoromequine sodium) flumequine powder
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English synonyms: r,r,b[]r,
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Special antibacterial drugs for animals
Fluomequine, also known as fluoquinoic acid and fluroquinoic acid, is a synthetic second-generation quinolone antibacterial drug for animals. It is also the only broad-spectrum antibacterial veterinary drug that is not shared with humans. It is fluoromequine. An alternative product to pipenic acid, it has strong bactericidal activity and is very effective in treating bacterial diseases in animals. Its main function is to inhibit the DNA gyrase of bacteria, interfering with the synthesis of DNA proteins, so that cells can no longer divide, thus playing a bactericidal effect. Mainly used for bacterial respiratory diseases of livestock and poultry, Escherichia coli, pullorum, salmonellosis, typhoid fever, fowl cholera, staphylococcal infectious rhinitis, etc. It has a strong inhibitory effect on colibacillosis, monospora and vibrio diseases of aquatic animals, and Aeromonas hydrophila.
Flumequine was first successfully developed by Rr Laboratory. Since the 1990s, it has been widely used in livestock, poultry and aquaculture in countries such as the European Union and Japan. It has great effect on diseases caused by various Gram-negative bacterial infections. It has good curative effect, especially on livestock, poultry and aquatic animal diseases caused by Escherichia coli, Mycoplasma and Aeromonas hydrophila. In my country, it was gradually developed and put on the market in the late 1990s, and it is mainly used for the prevention and treatment of bacterial infectious diseases such as salmon, trout, shrimp, eel, pigs, and chickens.
Because the quinolone antibacterial drug flumquine sodium can inhibit bacterial helicase, has a broad antibacterial spectrum, high efficiency, low toxicity, strong tissue penetration, and no anesthetic effect, it has become the most important drug in veterinary clinics and aquaculture. One of the anti-infective drugs, it is widely used for treatment, prevention and growth promotion. Due to its drug resistance and potential carcinogenicity, the European Union, Japan and my country have all set maximum residue limits in their tissues (both my country and the EU are b). At present, the detection methods for flumequine mainly include fluorescence spectrophotometry, enzyme-linked method and liquid chromatography. It has become a routine screening method due to its high sensitivity and easy operation.
Usage: It is a new broad-spectrum antibacterial synthetic drug that has good curative effect on animal bacterial diseases. It is suitable for livestock and poultry, seawater, freshwater fish, shrimps and crabs.
Mechanism of action: Flumequine achieves bactericidal effects by inhibiting the synthesis of bacterial nucleic acids and preventing bacterial replication. Mainly used for bacterial respiratory diseases of livestock and poultry, Escherichia coli, pullorum, salmonellosis, typhoid fever, fowl cholera, staphylococcal infectious rhinitis, etc. It has a strong inhibitory effect on colibacillosis, monospora and vibrio diseases of aquatic animals, and Aeromonas hydrophila.
Features Editor) It has a good effect. In addition to killing general bacteria, it is especially effective in gastrointestinal and respiratory tract infections.
) It is not easy to produce cross-resistant Gram-negative bacteria to this product. It is highly sensitive, has no cross-resistance with oxytetracycline, thiamphenicol, and erythromycin, and has partial cross-resistance with quinolones.
) The residue is small, and it only takes one day of drug withdrawal for pigs, and only one day of drug withdrawal for chickens and fish.
) It has a wide safety range, no adverse reactions, and no poisoning if doubled in dosage. Oral administration of flumequine is effective in river eels when they are young. g/kg and above. The concentration of flumequine in bathed freshwater prawns was above mg/L. Tests on mice show that it is mg ~ mg/kg. According to the general toxicity method and toxicity classification of new veterinary drugs of the Ministry of Agriculture, flumequine is of low toxicity and is safe for aquatic animals, livestock and poultry.
). Oral absorption is good. When flumquinequine is administered orally, % of the administered dose is absorbed by the intestines, and the blood concentration reaches a peak within ~ hours, and % is excreted within hours, and about % is excreted by the intestine. Excreted in the urine, % is excreted in the feces. After flumequine is absorbed into the body, the main metabolite is flumquine, accounting for about %, and the hydroxylated metabolite ~%.
Related products: Flumequine sodium
Properties: White crystalline powder, odorless
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Packing: cardboard drum
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