Sofosbuvir purchasing price in India 18801374745 Hepatitis C specific drug sofosbuvir

, ) ' h' Sofosbuvir is a hepatitis C virus nucleotide analog B polymerase inhibitor used as a component in combination antiviral regimens to treat chronic hepatitis C infection.
, ) ' h' >Sofosbuvir has been proven to be effective in the treatment of genotype, , or genotype hepatitis C subjects, including hepatocellular carcinoma subjects who meet Milan criteria and are waiting for liver transplantation, as well as subjects with H co-infection. tester.
, ) ' h' >Chronic hepatitis C can be treated in combination with ribavirin or ribavirin + pegylated interferon. The recommended combination treatment regimen is as follows
, ) ' h' >
, ) ' h' >Chronic hepatitis C patients who cannot use interferon can consider using sofosbuvir combined with ribavirin for weekly treatment.
, ) ' h' >Patients with hepatocellular carcinoma awaiting liver transplantation should be treated with sofosbuvir in combination with ribavirin for treatment of chronic hepatitis C for weeks or until liver transplantation, whichever occurs first.
, ) ' h' >Dosage recommendations cannot be given for patients with severe renal impairment or end-stage renal disease.
, ) ' h' >Contraindications
, ) ' h' >When sofosbuvir is used in combination with pegylated interferon h + ribavirin, or in combination with ribavirin alone, all Contraindications to peginterferon h or ribavirin also apply to sofosbuvir combination therapy.
, ) ' h' >Since ribavirin may cause fetal congenital malformation or stillbirth, sofosbuvir combined with pegylated interferon h + ribavirin, or sofosbuvir alone combined with ribavirin Bavirin should be contraindicated in women who are trying to become pregnant and in men whose partners are trying to become pregnant.
, ) ' h' >Warnings and Precautions
, ) ' h' >Bradycardia caused by coadministration with amiodarone: Use sofosbuvir in combination with antiviral drugs (D) to treat patients with H Severe symptomatic bradycardia may occur if amiodarone is taken concurrently, especially in patients who are concurrently taking beta-blockers or who have underlying cardiac complications and/or advanced liver disease.
, ) ' h' >Pregnancy: Ribavirin may cause fetal congenital malformations or stillbirth, and animal experiments show that interferon can cause miscarriage. Therefore, female patients taking this drug and the spouses of male patients should avoid pregnancy. Before starting treatment, patients must have a negative pregnancy test, use at least two non-hormonal methods of contraception, and undergo monthly pregnancy tests.
, ) ' h' >Adverse Reactions
, ) ' h' >The most common known adverse reactions caused by sofosbuvir combined with ribavirin (incidence equal to or greater than %, all grades) Headache and Fatigue The most common known adverse reactions caused by sofosbuvir combined with pegylated interferon h and ribavirin include fatigue, headache, nausea, insomnia and anemia.
, ) ' h' >Drug Interactions
, ) ' h' >Severe symptomatic bradycardia may occur when amiodarone is used concomitantly with sofosbuvir and antiviral drugs (D).
, ) ' h' >Powerful intestinal induction drugs (eg, rifampin, St. John's wort) may alter sofosbuvir concentrations.
, ) ' h' > Medication for special groups
, ) ' h' > H Co-infected patients: The safety and effectiveness of this drug have been confirmed by research.